Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease

Supported by Bayer. Disclosure creates provided by the writers are offered with the full text of this write-up at NEJM.org.

Dr. Eikelboom reports receiving give assistance and honoraria from Bayer, Boehringer Ingelheim, Bristol-Myers Squibb/Pfizer, Daiichi Sankyo, Janssen, AstraZeneca, Eli Lilly, GlaxoSmithKline, and also Sanofi-Aventis; Dr. Connolly, getting lecture fees and also consulting costs from Bristol-Myers Squibb, Pfizer, Portola Pharmaceuticals, Boehringer Ingelheim, Servier, Daiichi Sankyo, as well as Medtronic;

Dr. Hart, getting give support, costs for serving as major investigator of the Rivaroxaban versus Aspirin in Secondary Prevention of Stroke and also Prevention of Systemic Embolism in Patients with Recent Embolic Stroke of Undetermined Source (NAVIGATE ESUS)trial. And also advisory-board fees from Bayer; Dr. Diaz, receiving grant support from

the Population Health Research Institute; Dr. Alings, obtaining consulting charges from Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Pfizer, and also Sanofi-Aventis; Dr. Lonn, obtaining consulting charges from Bayer, Amgen, Sanofi, Novartis, and also Servier; Dr. Anand, getting consulting costs and also lecture costs from Bayer and also Novartis; Dr. Avezum, obtaining consulting fees from Boehringer Ingelheim;

Dr. Branch, obtaining give support from Astellas and also offering on a board of advisers for Janssen; Dr. Bhatt, obtaining give support from Amarin, AstraZeneca, Bristol-Myers Squibb, Eisai, Ethicon, Medtronic, Sanofi-Aventis, the Medicines Company, Roche, Pfizer, Forest Laboratories/AstraZeneca, Ischemix, Amgen, Eli Lilly, Chiesi, as well as Ironwood Pharmaceuticals, teaming up on research(uncompensated )with FlowCo, PLx Pharma, Takeda. And also Merck, receiving fees for serving on data checking boards, a procedures board, a publications board (USA co-national leader), and also a guiding board

from the Population Health Research Institute, acting as editor-in-chief of the Harvard Heart Letter for Belvoir Publications, working as chief medical editor of Cardiology Today’s Intervention for Slack Publications, getting costs for offering on proceeding medical education guiding boards from WebMD, getting advisory-board fees from Elsevier, serving on uncompensated advisory boards for Medscape Cardiology and Regado Biosciences, functioning as editor-in-chief of the Journal of Invasive Cardiology for HMP Communications, functioning as deputy editor for Clinical Cardiology, serving as visitor editor as well as associate editor for the Journal of the American College of Cardiology, working as chair of the research and publications committee of the Veterans Affairs Cardiovascular Assessment, Reporting. And Tracking system for the Department of Veterans Affairs, working as site coinvestigator for Biotronik and also Boston Scientific, serving on an unremunerated advisory board for Cardax, and obtaining costs for offering on data keeping an eye on boards from the Cleveland Clinic

, Duke University, and Mount Sinai School of Medicine; Dr. Zhu, getting lecture fees from Bayer, Boehringer Ingelheim, as well as Sanofi; Dr. Liang, getting lecture fees from Bayer, Boehringer Ingelheim, and Sanofi; Dr. Maggioni, receiving costs for acting as a research study committee member from Novartis, Bayer, Fresenius Medical Care, and also Cardiorentis; Dr. Kakkar, getting grant assistance as well as charges for serving as guiding board chairman from Bayer, and consulting costs from Boehringer Ingelheim, Daiichi Sankyo Europe, Janssen, Sanofi, and Armetheon; Dr. Fox, getting grant assistance as well as honoraria from AstraZeneca and honoraria from Sanofi/Regeneron Pharmaceuticals; Dr. Parkhomenko, receiving grant support and also honoraria from Pfizer, Bayer, Janssen, AstraZeneca, Sanofi, and Merck Sharp Dohme; Dr. Störk, obtaining grant assistance from Servier and Boehringer Ingelheim, give assistance as well as lecture fees from Novartis and also Thermo Fisher Scientific, as well as lecture costs from Pfizer; Dr. Ryden, getting give support from Amgen as well as Bayer, give assistance, charges for offering on professional committees, and also lecture costs from Boehringer Ingelheim and Novo Nordisk, and also lecture costs from Merck Sharp Dohme; Dr. Dans, receiving lecture fees from Pfizer and also Boehringer Ingelheim; Dr. Torp-Pedersen, receiving give support from Biotronik; Dr. Verhamme, getting grant assistance, lecture costs, and consulting costs from Bayer HealthCare, Boehringer Ingelheim,

Daiichi Sankyo, Pfizer, as well as Bristol-Myers Squibb, grant support from Sanofi as well as Leo Pharma, and consulting fees from Portola Pharmaceuticals; Dr. Vinereanu, receiving grant assistance, lecture charges, and consulting fees from Boehringer Ingelheim, Pfizer, and also Novartis as well as grant assistance as well as lecture fees from Servier; Dr. Lewis, getting lecture charges and gratuity from Pfizer/Bristol-Myers Squibb; Dr. Steg, receiving costs for offering on a guiding board from Amarin, Janssen. And Also CSL Behring, costs for serving on a steering committee and also lecture charges from AstraZeneca, lecture fees and also getting in touch with charges from Bayer and also Bristol-Myers Squibb, charges for prep work of academic product from Boehringer Ingelheim, getting in touch with costs and fees for offering on a data and safety tracking board from Eli Lilly as well as Merck Sharp Dohme, getting in touch with costs from Novartis and also Regeneron Pharmaceuticals, fees for serving on a critical-event board from Pfizer, charges for offering on a guiding board and also consulting charges from Sanofi, and fees for offering on a guiding committee, seeking advice from charges, and costs for serving on a data and safety and security monitoring board from Servier. Dr. Cook Bruns, being used by Bayer; Dr. Misselwitz, being used by and being a shareholder of Bayer as well as

holding a patent (United States 9539218 B2 as well as EP 1845961 B1) on the once-daily use of rivaroxaban; Dr. Chen, being used by Bayer HealthCare; as well as Dr. Yusuf, getting grant assistance and also honoraria from Bayer, Boehringer Ingelheim, AstraZeneca, Bristol-Myers Squibb, and Cadila Pharmaceuticals. No other potential problem of passion relevant to this short article was reported. This article was published on August 27, 2017, and upgraded on October 5, 2017, at NEJM.org.

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